Creating a database to improve cancer drug combination trials
An informatics bridge over the valley of death for cancer Phase I trials of drug-combination therapies
This study is working on creating a helpful database that gathers information about how different cancer drugs can affect each other, so researchers can find better combinations of treatments and improve the chances of success in early trials.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10694008 on NIH RePORTER |
What this research studies
This research aims to develop a comprehensive database that integrates existing data on drug toxicity and pharmacokinetics for cancer therapies. By focusing on drug combinations, the project seeks to address the high failure rate of Phase I trials, which often overlook critical interactions between drugs. The methodology involves using advanced data mining techniques to extract relevant information from existing literature, thereby creating a translational drug-interaction knowledgebase. This knowledgebase will help researchers better understand how different cancer drugs interact, potentially leading to more effective treatment combinations.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who may benefit from novel drug combination therapies.
Not a fit: Patients who are not undergoing treatment for cancer or those who have exhausted all treatment options may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly enhance the success rates of early-phase cancer drug trials, leading to more effective treatment options for patients.
How similar studies have performed: Previous research has shown that integrating data from multiple sources can improve drug development processes, suggesting that this approach has the potential for success.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Li, Lang — Ohio State University
- Study coordinator: Li, Lang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.