Creating a computer model to understand blood flow changes in diabetic retinopathy
Official title: Development and application of a high-fidelity computational model of diabetic retinopathy hemodynamics: Coupling single-cell biophysics with retinal vascular network topology and complexity
Funded at Rutgers, the State Univ of N.j. · NIH-11168170 · Data updated 2026-11-12
This study is creating a computer model to better understand how diabetes affects blood flow in the eyes of people with diabetic retinopathy, helping to reveal how these changes can lead to eye problems that current tests might miss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $131,000 |
| NIH project number | 3R01EY033003-04S1 |
| Project ID | NIH-11168170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with diabetic retinopathy.
✕Less likely to help
Patients without diabetes or those who do not have diabetic retinopathy may not benefit from this research.
What this research studies
This research focuses on developing a high-performance computer model to simulate blood flow dynamics in the eyes of individuals with diabetic retinopathy. By analyzing how diabetes affects the biophysical properties of blood cells and their impact on retinal blood vessels, the study aims to uncover the mechanisms behind the disease's progression. The model will help predict how changes in blood flow and oxygen levels contribute to the development of retinal abnormalities. This innovative approach seeks to provide insights that current imaging techniques cannot offer.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for diabetic retinopathy, potentially preventing vision loss.
How similar studies have gone: While there have been studies on diabetic retinopathy, this specific approach using high-fidelity computational modeling is relatively novel and has not been extensively tested.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Bagchi, Prosenjit — Rutgers, the State Univ of N.j.
- Study coordinator: Bagchi, Prosenjit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.