Creating a comprehensive human genetic reference
Human Pangenome Reference
This study is working to create a comprehensive genetic map that includes DNA from people all around the world, so that everyone can benefit equally from genetic research and healthcare.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10907974 on NIH RePORTER |
What this research studies
This research aims to develop a complete human pangenome reference that includes genetic information from individuals of diverse biogeographical backgrounds. By identifying and including a wide range of genetic variations, the project seeks to ensure that the pangenome serves all populations equitably. The methodology involves building haplotype-resolved reference assemblies, creating gene annotations, and developing tools for the scientific community to utilize this resource effectively. The project emphasizes community engagement and feedback to enhance the utility of the pangenome for various applications in genomics.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals from various biogeographical ancestries who are willing to contribute their genetic information.
Not a fit: Patients with very rare genetic backgrounds or those who do not wish to share their genetic data may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate genetic insights and personalized medicine for diverse populations.
How similar studies have performed: Previous research in genomics has shown that inclusive genetic references can significantly improve health outcomes and treatment efficacy across diverse populations.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Wang, Ting — Washington University
- Study coordinator: Wang, Ting
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.