Creating a comprehensive atlas of gene expression in developing human tissues
Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Human Genotype-Tissue Expression Project
This study is looking at how our genes affect brain development from childhood to teenage years, helping us understand how different brain cells work and how this knowledge might improve our understanding of brain function for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10927294 on NIH RePORTER |
What this research studies
This research focuses on generating and analyzing genomic data from various human tissues, particularly brain regions, across different developmental stages from infancy to adolescence. By integrating genotyping and functional genomic data, the project aims to predict how genetic variations affect gene expression during critical periods of brain development. The research will also address gaps in understanding how these genetic factors influence specific cell types, which is essential for comprehending the complexities of human development. Patients may benefit from insights gained about genetic influences on brain function and development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include children and adolescents from infancy to late childhood who may have developmental concerns or genetic conditions.
Not a fit: Patients who are adults or those with conditions unrelated to genetic influences on brain development may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic factors that influence brain development and function, potentially leading to improved treatments for developmental disorders.
How similar studies have performed: Previous research efforts, such as the GTEx project, have shown success in studying adult and prenatal gene expression, but this project aims to fill a novel gap in understanding postnatal development.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sestan, Nenad — Yale University
- Study coordinator: Sestan, Nenad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.