Creating a 3D skin model to study human herpes simplex virus infection
Modeling of human HSV infection: development of immune-competent 3D skin-on-chip with vascular perfusion
This study is creating a special 3D model of human skin to help researchers learn how the herpes virus interacts with our immune system, which could lead to better treatments for people dealing with this infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10761735 on NIH RePORTER |
What this research studies
This research focuses on developing a three-dimensional (3D) skin-on-chip model that mimics human tissue to better understand how the herpes simplex virus (HSV) infects and interacts with the immune system. By using this advanced model, researchers aim to replicate the complex interactions that occur in human skin, which traditional 2D cell cultures and animal models cannot accurately represent. The goal is to improve drug testing and efficacy assessments for treatments targeting HSV and other infectious diseases, ultimately leading to better therapeutic options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are affected by herpes simplex virus infections.
Not a fit: Patients with other types of infections or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for herpes simplex virus infections and potentially other infectious diseases.
How similar studies have performed: Other research has shown promise in using 3D tissue models for studying infectious diseases, indicating that this approach could be a significant advancement in the field.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Zhu, Jia — University of Washington
- Study coordinator: Zhu, Jia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.