Creating a 3D skin model to study aging
Senescence-on-a-chip: Building a microphysiological 3D skin model
This study is looking at how our skin ages and how things like sunlight can affect it by creating a special 3D model of skin cells, which will help researchers learn more about skin health and age-related skin issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11178122 on NIH RePORTER |
What this research studies
This research investigates the aging process of human skin by developing a sophisticated 3D skin model that mimics the natural environment of skin cells. The model will help researchers understand how skin cells age and how environmental factors, like UV radiation, contribute to skin disorders and inflammation. By analyzing the behavior of skin cells, particularly those that become senescent, the research aims to uncover the mechanisms behind age-related skin conditions. This approach allows for a controlled study of cellular interactions and their effects on skin health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing age-related skin conditions or those concerned about skin aging.
Not a fit: Patients with acute skin injuries or conditions unrelated to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for age-related skin disorders and improved skin health.
How similar studies have performed: Other research has shown promise in using 3D models to study skin aging, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Christiano, Angela M — Columbia University Health Sciences
- Study coordinator: Christiano, Angela M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.