Creating a 3D printed platform to study blood vessel health and disease
Official title: Development of a Collagen-based 3D Bioprinted Microfluidic Platform for Vascular Tissue Engineering and Disease Modeling
Funded at University of Pittsburgh at Pittsburgh · NIH-10850711 · Data updated 2026-11-12
This study is working on creating a 3D model of blood vessels to help us learn more about high blood pressure and how it affects your health, so we can find better ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL155777-04 |
| Project ID | NIH-10850711 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are affected by hypertensive vascular disease.
✕Less likely to help
Patients with non-vascular related conditions or those under 21 years old may not receive benefits from this research.
What this research studies
This research focuses on developing a 3D bioprinted platform that mimics blood vessels to better understand and treat hypertensive vascular disease. By using collagen and advanced printing techniques, the project aims to create small artery models that can replicate the natural behavior of blood vessels. Patients can benefit from this research as it seeks to uncover how changes in the structure and signaling of blood vessels contribute to high blood pressure and related health issues. The study will also utilize innovative biosensors to measure how these engineered tissues respond to various stimuli, providing insights into vascular health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for hypertension and related vascular diseases.
How similar studies have gone: Previous research has shown promise in using 3D bioprinting for tissue engineering, indicating a potential for success in this novel approach.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Shiwarski, Daniel J — University of Pittsburgh at Pittsburgh
- Study coordinator: Shiwarski, Daniel J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.