Creating a 3D model to understand a serious heart defect in infants.
Official title: A Dynamic and Three-Dimensional Human Model of Hypoplastic Left Heart Syndrome to Probe Compromised Cardiomyocyte Proliferation
Funded at Research Inst Nationwide Children's Hosp · NIH-10900007 · Data updated 2026-11-12
This study is creating a 3D model of the heart to better understand hypoplastic left heart syndrome (HLHS) and improve heart cell growth, which could lead to new treatments for this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | September 16, 2024 |
| Project end | September 15, 2027 |
| Funding year | 2024 |
| Award (this year) | $76,756 |
| NIH project number | 1F32HL170581-01A1 |
| Project ID | NIH-10900007 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants diagnosed with hypoplastic left heart syndrome or those at risk for developing this condition.
✕Less likely to help
Patients with other congenital heart defects that do not involve the left side of the heart may not benefit from this research.
What this research studies
This research focuses on hypoplastic left heart syndrome (HLHS), a congenital heart defect where the left side of the heart is underdeveloped. The team aims to develop a dynamic three-dimensional model that mimics the human heart's structure and function, allowing for better understanding of the disease's cellular processes. By using 3D cell culture techniques, they hope to improve the growth and function of heart cells, which could lead to new insights into HLHS and potential treatments. This model will help bridge the gap between animal studies and human conditions, providing a more accurate representation of the disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and outcomes for infants with hypoplastic left heart syndrome.
How similar studies have gone: Previous research using 3D modeling techniques has shown promise in understanding other cardiac conditions, suggesting potential success for this novel approach.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Alonzo, Matthew — Research Inst Nationwide Children's Hosp
- Study coordinator: Alonzo, Matthew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.