Creating a 3D model to study the immune response to infections in humans
An Integrated In Vitro 3D Model of Human Bone Marrow and Peripheral Infection
This study is looking at how our immune system fights infections by seeing how it works with bone marrow to make immune cells, using a special 3D model to get a better understanding that could help improve treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10852886 on NIH RePORTER |
What this research studies
This research focuses on understanding how the human immune system responds to infections, particularly how it engages the bone marrow to produce immune cells. By developing a 3D model called the 'ImmuneChip', researchers aim to replicate the interactions between bone marrow, blood circulation, and sites of infection. This innovative approach utilizes advanced cell culture techniques to better mimic human responses compared to traditional animal models. Patients may benefit from insights gained about immune responses and antibiotic resistance, which could lead to improved treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with bacterial infections or those at risk of developing antibiotic resistance.
Not a fit: Patients with non-bacterial infections or those not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses and combating antibiotic-resistant infections.
How similar studies have performed: Other research has shown promise in using 3D models to study immune responses, indicating that this approach could yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: George, Steven Carl — University of California at Davis
- Study coordinator: George, Steven Carl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.