Creating a 3D model to study lung fibrosis similar to Idiopathic Pulmonary Fibrosis
Validation of an in vitro model of progressive fibrosis that mimics Idiopathic Pulmonary Fibrosis
['FUNDING_U01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10763361
This study is creating a special 3D model of Idiopathic Pulmonary Fibrosis (IPF) using stem cells to better understand the disease and find new treatments that could work for different patients.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10763361 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a three-dimensional bioengineered model of Idiopathic Pulmonary Fibrosis (IPF) using human induced pluripotent stem cells. The model aims to replicate the progressive fibrosis seen in IPF, allowing researchers to study the disease's characteristics and test potential treatments. By utilizing specific lung cell types and architecture, the model will help in understanding the disease's heterogeneity and genetic risk factors. Ultimately, this research seeks to create a platform for high-throughput drug discovery tailored to individual patient needs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Idiopathic Pulmonary Fibrosis or those at risk due to genetic factors.
Not a fit: Patients with other forms of lung disease or those without a diagnosis of pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients with Idiopathic Pulmonary Fibrosis.
How similar studies have performed: Previous research has shown promise in using bioengineered models for studying lung diseases, indicating that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOMPERTS, BRIGITTE N — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: GOMPERTS, BRIGITTE N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.