Creating a 3D model to study kidney development
Official title: Nephrogenesis on a chip: an simple modular platform to spatially pattern extracellular matrix, stromal cells, and soluble factors
Funded at University of Delaware · NIH-11039098 · Data updated 2026-11-12
This study is creating a special 3D model of a developing kidney to help scientists learn how kidney cells grow and what affects their development, which could lead to better understanding and treatment of kidney diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | September 6, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $238,184 |
| NIH project number | 1R21DK142145-01 |
| Project ID | NIH-11039098 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting kidney development or function, as well as those interested in advancements in kidney disease treatment.
✕Less likely to help
Patients with fully developed kidneys and no history of kidney disease may not benefit directly from this research.
What this research studies
This research focuses on developing a modular 3D model that mimics the environment of the developing kidney, allowing scientists to study how different factors influence kidney cell development. By spatially organizing extracellular matrix components, stromal cells, and soluble factors, the model aims to replicate the conditions necessary for nephron formation. This innovative approach will enable researchers to better understand the mechanisms behind kidney development and disease, providing a valuable tool for future studies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of kidney diseases by providing insights into nephron development.
How similar studies have gone: Other research has shown success with similar 3D modeling approaches in studying organ development, indicating potential for this method to yield valuable insights.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Gleghorn, Jason Paul — University of Delaware
- Study coordinator: Gleghorn, Jason Paul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.