Creating a 3D model to study immune interactions in type 1 diabetes
Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions
['FUNDING_OTHER'] · UNIVERSITY OF FLORIDA · NIH-10665727
This study is creating a special lab model that looks like human tissue to see how immune cells affect insulin-producing cells in type 1 diabetes, which could help find new ways to treat the condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10665727 on ClinicalTrials.gov |
What this research studies
This research aims to develop a three-dimensional microphysiological system (MPS) that mimics human tissues to better understand how immune cells interact with insulin-producing cells in type 1 diabetes. By using human cells and advanced technologies, the researchers will create a platform that allows for the observation of these complex interactions in a controlled environment. This model will help identify how specific immune responses contribute to the destruction of insulin-producing cells, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes or those at risk of developing the condition.
Not a fit: Patients with type 2 diabetes or other forms of diabetes unrelated to immune interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with type 1 diabetes.
How similar studies have performed: Previous research using similar 3D modeling approaches has shown promise in understanding immune responses and disease mechanisms, indicating potential for success in this novel application.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STABLER, CHERIE L — UNIVERSITY OF FLORIDA
- Study coordinator: STABLER, CHERIE L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.