Creating a 3D model to study brain hemorrhages and test new treatments
Official title: Development of a 3D neurovascular unit for in vitro modeling of subarachnoid hemorrhage and screening therapies
Funded at Vanderbilt University · NIH-10908621 · Data updated 2026-11-12
This study is creating a 3D model of the brain's blood vessels to help us understand subarachnoid hemorrhage (SAH) better and find new treatments, so patients with this type of stroke can have more effective options for recovery.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $112,872 |
| NIH project number | 5K99NS133399-02 |
| Project ID | NIH-10908621 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced subarachnoid hemorrhage or are at risk for this condition.
✕Less likely to help
Patients with conditions unrelated to subarachnoid hemorrhage or those who do not have neurological disorders may not benefit from this research.
What this research studies
This research focuses on developing a three-dimensional (3D) model of the brain's blood vessels to better understand subarachnoid hemorrhage (SAH), a type of stroke caused by bleeding in the brain. By using advanced 3D printing techniques and microfluidic devices, the team aims to simulate the conditions of SAH and explore potential therapies using nanoparticles. Patients can benefit from this research as it seeks to improve treatment options for those affected by SAH and related neurological conditions. The project combines training in vascular biology and therapeutic development to create innovative solutions for brain health.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from subarachnoid hemorrhage and improve recovery outcomes.
How similar studies have gone: Other research has shown promise in using 3D models for studying neurological conditions, indicating that this approach could be effective.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: O'grady, Brian J — Vanderbilt University
- Study coordinator: O'grady, Brian J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.