Creating a 3D model of the human neural tube using microfluidics
Official title: A Fully Patterned Human Neural Tube Model Using Microfluidics
Funded at University of Michigan at Ann Arbor · NIH-11098583 · Data updated 2026-11-12
This study is creating a 3D model of the early human brain and spinal cord to help scientists learn how problems in their development can cause conditions like spina bifida, with the hope of finding better treatments for people affected by these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $523,443 |
| NIH project number | 5R01NS129850-03 |
| Project ID | NIH-11098583 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodevelopmental disorders or those at risk of developing such conditions.
✕Less likely to help
Patients with fully developed neurological conditions unrelated to neurodevelopmental disorders may not benefit from this research.
What this research studies
This research focuses on developing a fully patterned human neural tube model that mimics the early stages of central nervous system development. By utilizing microfluidic technology, the project aims to create a 3D environment that accurately represents the neural tube's structure and function. This model will help researchers understand how deviations in neural tube formation can lead to neurodevelopmental disorders. Patients may benefit from insights gained through this model, which could lead to improved treatments for neurological and psychiatric conditions.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for neurodevelopmental disorders.
How similar studies have gone: Other research has shown promise in using stem cell-based models for studying neural development, but this specific approach is novel.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Fu, Jianping — University of Michigan at Ann Arbor
- Study coordinator: Fu, Jianping
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.