Creating a 3D model of the heart's natural pacemaker cells
Reverse Tissue-Manufacturing of the Multicellular Sinoatrial Node Organoids
This study is creating a tiny, 3D model of the heart's natural pacemaker to help us learn how it works and find better treatments for heart rhythm problems like arrhythmia, which could lead to improved care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11049043 on NIH RePORTER |
What this research studies
This research focuses on developing a three-dimensional multicellular organoid that mimics the sinoatrial (SA) node, which is responsible for regulating heart rhythm. By recreating the complex structure and function of the SA node, the study aims to better understand how pacemaker cells work and how they can be used to treat conditions like arrhythmia. The approach involves advanced tissue engineering techniques to produce a more effective biological pacemaker that can maintain stable heart rhythms. Patients may benefit from improved therapies for heart rhythm disorders as a result of this innovative model.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing sinoatrial node dysfunction or related cardiac arrhythmias.
Not a fit: Patients with non-cardiac related health issues or those who do not have arrhythmias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with heart rhythm disorders.
How similar studies have performed: Other research has shown promise in developing biological pacemakers, but this approach of creating a 3D multicellular organoid is relatively novel.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Park, Sung Jin — Emory University
- Study coordinator: Park, Sung Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.