Creating a 3D model of the feto-maternal interface to test drugs that may prevent preterm birth
3-D biofabricated feto-maternal interface tissue model to determine drug efficacy during pregnancy to reduce the risk of preterm birth
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-10915205
This study is creating a special 3D model of the connection between a mother and her baby to learn how different medications might affect pregnancy and help prevent early births, which could lead to better treatments for expectant moms.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-10915205 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a 3D biofabricated model of the feto-maternal interface to better understand how drugs can affect pregnancy and potentially reduce the risk of preterm birth. By using primary human cells, the researchers aim to create a high-throughput tissue chip that allows for extensive testing of various drugs to see how they interact with the feto-maternal interface. This model addresses the limitations of current testing methods, which often do not accurately reflect human responses. Patients may benefit from this research as it could lead to more effective treatments for preventing preterm birth.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals at risk of preterm birth due to inflammatory responses or other related factors.
Not a fit: Patients who are not pregnant or those who do not have risk factors for preterm birth may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved drug therapies that significantly reduce the incidence of preterm birth.
How similar studies have performed: Previous research has shown promise in using tissue models for drug testing, but this specific approach using a 3D bioprinted feto-maternal interface is relatively novel.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MENON, RAMKUMAR — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: MENON, RAMKUMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.