Creating a 3D model of human cerebellar neurons
A Bioengineering Approach to Develop a Laminar 3D Cerebellar Neuronal Circuit for Modeling Human Cerebellum
['FUNDING_R01'] · SEATTLE CHILDREN'S HOSPITAL · NIH-11055980
This study is creating a special 3D model of brain cells to better understand how cerebellar neurons work together, which could help us learn more about their role in movement and thinking, and it's designed for anyone interested in brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11055980 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a three-dimensional (3D) culture system that accurately mimics the structure of human cerebellar neurons. By using human pluripotent stem cells, the team will differentiate these cells into specific types of cerebellar neurons and create a layered model that reflects the natural organization of the cerebellum. The project will also involve advanced imaging techniques to study how these neurons interact and function within this 3D environment, providing insights into their roles in both motor and cognitive functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting the cerebellum, such as ataxia or other neurological disorders.
Not a fit: Patients with conditions unrelated to cerebellar function or those who do not have access to the research facility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of cerebellar disorders, potentially improving outcomes for patients with related neurological conditions.
How similar studies have performed: While the approach of creating 3D neuronal models is gaining traction, this specific application to human cerebellar neurons is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLEN, KATHLEEN JOYCE — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: MILLEN, KATHLEEN JOYCE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.