Creating a 3D Cervix Model to Improve HPV and Cervical Cancer Detection
Development of a Physiologically Replete Cervix Model with Three-Dimensional Cellular Co-Culture for the Evaluation of High-Risk Human Papillomavirus and Cervical Cancer Biomarkers
This work aims to create better ways to find high-risk human papillomavirus (HPV) and early signs of cervical cancer, especially in places with limited healthcare resources.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11308756 on NIH RePORTER |
What this research studies
Cervical cancer is largely preventable with early detection, but many people in low-resource settings still face high rates of illness and death. Current tests often look for HPV DNA, which can lead to unnecessary treatments because it doesn't always show if an infection will cause cancer. This project focuses on developing new methods to detect HPV mRNA, a more specific sign of higher-grade precancerous changes. We are building a realistic 3D model of the cervix and developing a simple, affordable mRNA test that can be used with self-collected samples, making it easier to identify those truly at risk.
Who could benefit from this research
Good fit: This research is foundational for individuals at risk for high-risk HPV infection and cervical cancer, particularly those in low-resource settings who lack access to current screening methods.
Not a fit: Patients who are not at risk for HPV or cervical cancer, or those already receiving comprehensive care, may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more accurate and accessible early detection tests for cervical cancer, reducing overtreatment and improving outcomes for patients worldwide.
How similar studies have performed: While the concept of using mRNA as a biomarker is gaining traction, this specific approach to developing a physiologically accurate 3D cervix model and an integrated, low-cost mRNA test for low-resource settings is novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Novak, Emilie Newsham — University of Washington
- Study coordinator: Novak, Emilie Newsham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.