Creating a 3D brain model to understand resilience to Alzheimer's disease
3D Brain Tissue System for Modeling Resilience to Alzheimer's Disease and Drug Discovery
This study is exploring why some people stay mentally sharp even if they have genes that make them more likely to get Alzheimer's, and it's for anyone interested in finding new ways to prevent or treat this disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10848925 on NIH RePORTER |
What this research studies
This research investigates how some individuals remain cognitively healthy despite having a genetic predisposition to Alzheimer's disease. By using a genetically diverse mouse model, the team aims to uncover the mechanisms behind cognitive resilience. They will develop a 3D co-culture system that mimics the human brain's structure and function, allowing for the testing of potential therapeutic compounds that could enhance cognitive resilience. The findings could lead to new strategies for preventing or treating Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients who are already diagnosed with advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that help protect against cognitive decline in Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using similar models to understand cognitive resilience, indicating potential for success in this approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Kaczorowski, Catherine Cook — University of Michigan at Ann Arbor
- Study coordinator: Kaczorowski, Catherine Cook
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.