Creating a 3D bioelectric bridge to improve heart function
Official title: 3D Bioprinting of a Bioelectric Cell Bridge for Re-engineering Cardiac Conduction
Funded at Brown University · NIH-10883643 · Data updated 2026-11-12
This study is exploring a new way to help people with heart rhythm problems by using a special 3D bridge made from natural materials and heart cells to connect areas of the heart that are too far apart, which could help restore normal heart function and reduce irregular heartbeats.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $200,514 |
| NIH project number | 5R21EB035030-02 |
| Project ID | NIH-10883643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from arrhythmias or other cardiac conduction disorders.
✕Less likely to help
Patients with stable heart conditions or those who do not have issues with cardiac conduction may not benefit from this research.
What this research studies
This research investigates a new method to treat heart rhythm disorders by developing a 3D bioelectric cell bridge made from natural materials and heart cells. The goal is to create a continuous connection between heart cells that are too far apart, which can help restore normal heart function and reduce the risk of arrhythmias. By using advanced bioprinting techniques, the researchers aim to enhance the electrical connections in the heart, potentially leading to better outcomes for patients with cardiac conditions. This innovative approach seeks to integrate biological materials with heart tissue to improve long-term heart health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with heart rhythm disorders, potentially reducing the need for electronic devices.
How similar studies have gone: While this approach is innovative, similar research in cardiac tissue engineering has shown promise, indicating potential for success.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Coulombe, Kareen Lk — Brown University
- Study coordinator: Coulombe, Kareen Lk
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.