Creating 3D printed urethral tissue for better surgical outcomes
Official title: Engineering biomimetic 3D printed urethral tissue constructs using elastin-based bioinks for urethroplasty
Funded at University of California Los Angeles · NIH-11173680 · Data updated 2026-11-12
This study is exploring a new way to create stretchy, natural-looking tissue for repairing the urethra using 3D printing and special materials made from human proteins, which could help improve healing for people needing surgery for urethral problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $212,625 |
| NIH project number | 5R21EB035280-02 |
| Project ID | NIH-11173680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals, both children and adults, who require urethroplasty due to congenital, traumatic, infectious, or malignant conditions.
✕Less likely to help
Patients with urethral defects that are not suitable for surgical intervention or those who do not have access to the required healthcare facilities may not benefit from this research.
What this research studies
This research focuses on developing advanced 3D printed urethral tissue constructs using innovative bioinks made from human proteins and decellularized matrices. The goal is to create highly elastic, biomimetic tissues that can be used in urethroplasty, a surgical procedure for repairing urethral defects. By employing a unique 3D bioprinting technique, the researchers aim to replicate the natural structure and properties of urethral tissue, enhancing healing and function. This approach addresses the limitations of current tissue sources, which often lead to complications and suboptimal outcomes.
Why it matters
Potential benefit: If successful, this research could provide patients with safer and more effective options for urethral repair, reducing complications and improving quality of life.
How similar studies have gone: Previous research in the field of bioprinting and tissue engineering has shown promising results, indicating that this approach could lead to significant advancements in urethral repair.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Annabi, Nasim — University of California Los Angeles
- Study coordinator: Annabi, Nasim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.