Creating 3D printed tissues and organs using advanced computer modeling.
Official title: Multiscale Computational Modeling to Design Patterned Tissue Assembloids for Biomanufacturing
Funded at University of Virginia · NIH-10999951 · Data updated 2026-11-12
This study is exploring new ways to create complex tissues and organs using advanced technology, which could help patients by making it easier to produce healthy tissues for transplants or healing.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $169,702 |
| NIH project number | 1R21EB035402-01A1 |
| Project ID | NIH-10999951 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions requiring tissue or organ transplants, such as organ failure or severe injuries.
✕Less likely to help
Patients with conditions that do not require tissue engineering or organ replacement may not benefit from this research.
What this research studies
This research focuses on developing innovative computational models to design and fabricate complex tissues and organs through biomanufacturing. By utilizing advanced algorithms and machine learning, the project aims to predict how different types of cells can be combined and organized into specific patterns. Patients may benefit from this research as it could lead to the mass production of functional tissues and organs for transplantation or regenerative medicine. The approach involves engineering cells with synthetic gene circuits to enhance their interactions and adhesion, ultimately improving tissue formation.
Why it matters
Potential benefit: If successful, this research could enable the production of custom tissues and organs for patients in need of transplants.
How similar studies have gone: While the approach is innovative, similar research in tissue engineering has shown promising results, indicating potential for success.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Lazzara, Matthew J — University of Virginia
- Study coordinator: Lazzara, Matthew J
Related research
Other NIH-funded projects on the same topics.
-
STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)
This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.
-
Steroids and better antibiotics for sepsis in people with AIDS in Africa
This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
-
Predictive tools to improve pediatric donor heart use
A pediatric heart transplant grant is building data-driven tools to help doctors choose the best donor hearts for children.
-
Microglia Help Finish Seizures and Heal the Brain
Scientists are studying how brain immune cells (microglia) help end severe seizures and repair brain damage, with potential new ideas for people who have had status epilepticus.
-
Small molecules that boost the 20S proteasome to fight Alzheimer’s and related dementias
A new approach tests small molecules that activate the 20S proteasome to help neurons clear harmful proteins and slow the spread of disease in people affected by Alzheimer's and related dementias.
-
Advanced genome and transcriptome analysis with long-read sequencing
A researcher at a university is using long-read DNA and RNA sequencing to map complete genomes and transcriptomes for individuals to understand how genetic variations relate to disease risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.