Creating 3D-printed bioinks for regenerating bone tissue
In situ bioprinting of high-density cell-laden core-shell microgel bioinks enabling cellular condensation for vascularized bone tissue regeneration
['FUNDING_OTHER'] · JESSE BROWN VA MEDICAL CENTER · NIH-11072099
This study is exploring a new way to help military personnel and veterans heal from bone injuries in their face by using 3D printing to create special gels filled with stem cells that can be placed directly into the body to help grow new bone tissue.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JESSE BROWN VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11072099 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new method for regenerating craniofacial bone tissue in military personnel and veterans who have suffered injuries from combat. The approach involves using advanced 3D bioprinting technology to create biodegradable microgels that are loaded with human mesenchymal stem cells. These microgels can be implanted directly into the body without needing prior lab culture, allowing for immediate tissue formation and integration. By customizing the structure of these bioinks, the research aims to match the specific bone defects of individual patients, enhancing the potential for successful regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are military personnel and veterans who have experienced significant craniofacial bone damage due to combat-related injuries.
Not a fit: Patients with non-combat related bone injuries or those who do not have craniofacial bone damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a groundbreaking solution for effectively regenerating functional bone tissue in patients with severe injuries.
How similar studies have performed: While the approach of using 3D bioprinting for tissue regeneration is innovative, similar strategies have shown promise in other areas of regenerative medicine, indicating potential for success.
Where this research is happening
CHICAGO, UNITED STATES
- JESSE BROWN VA MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALSBERG, EBEN — JESSE BROWN VA MEDICAL CENTER
- Study coordinator: ALSBERG, EBEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.