Creating 3D models to study sexually transmitted infections.
Structure, immunity and microbiome: Human 3D biomimetics cervicovaginal models for sexually transmitted infections (SIM-STI)
['FUNDING_OTHER'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11059855
This study is creating special 3D models that look like the cervix and vagina to help us learn more about how infections like chlamydia and gonorrhea happen and affect health, especially in relation to the body's natural bacteria.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11059855 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced three-dimensional models that mimic the human cervicovaginal environment to better understand sexually transmitted infections (STIs) like chlamydia and gonorrhea. By using these biomimetic models, researchers aim to investigate how these infections occur, persist, and lead to serious health issues such as pelvic inflammatory disease and infertility. The study will also explore the role of the cervicovaginal microbiome in influencing susceptibility to these infections. This innovative approach combines engineering and microbiology to provide insights that traditional models cannot offer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for or currently experiencing sexually transmitted infections, particularly those affected by chlamydia or gonorrhea.
Not a fit: Patients who are not at risk for sexually transmitted infections or those who have already been effectively treated may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for sexually transmitted infections.
How similar studies have performed: While there has been significant research on STIs, the use of advanced 3D biomimetic models represents a novel approach that has not been extensively tested in this context.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAVEL, JACQUES — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: RAVEL, JACQUES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.