Creating 3D models to study Alzheimer's disease mechanisms
Human 3D Neuro-Vascular Interaction and Meningeal Lymphatic Models with Application to Alzheimer’s Disease
This study is creating a special 3D model of the brain to help us learn more about Alzheimer's disease and how different parts of the brain work together, which could lead to new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11081647 on NIH RePORTER |
What this research studies
This research focuses on developing advanced three-dimensional (3D) models that replicate the human brain environment to better understand Alzheimer's disease (AD). By integrating components such as the blood-brain barrier and meningeal lymphatics, the study aims to investigate how these systems interact and contribute to the progression of AD. The approach involves using stem-cell-derived cells to create a realistic in vitro model that can help identify specific mechanisms involved in AD pathology. This could lead to new insights and potential therapeutic targets for treating Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's disease or those without any cognitive impairment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for Alzheimer's disease by uncovering critical mechanisms involved in its progression.
How similar studies have performed: Other research has shown promise in using 3D models to study neurological diseases, indicating that this approach could yield valuable insights into Alzheimer's disease mechanisms.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Kamm, Roger D — Massachusetts Institute of Technology
- Study coordinator: Kamm, Roger D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.