Creating 3D models of lymph nodes to study immune responses
3D biomimetic lymph node engineered extracellular vesicles for understanding the heterogeneity of adaptive immunity
This study is creating a 3D model of lymph nodes to learn how immune cells talk to each other and react to different things, which could help us understand how your immune system works and how it responds to illnesses or treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10727055 on NIH RePORTER |
What this research studies
This research focuses on developing a 3D biomimetic model of lymph nodes to better understand how immune cells communicate and respond to various stimuli. By utilizing advanced techniques to isolate and analyze tiny vesicles that play a crucial role in immune signaling, the study aims to uncover the complexities of immune responses in a more realistic environment. Patients may benefit from insights gained into how their immune systems function and respond to diseases or therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that affect the immune system or those interested in understanding their immune responses better.
Not a fit: Patients with stable, non-immune related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of immune responses, potentially enhancing treatments for various immune-related conditions.
How similar studies have performed: Other research has shown promise in using biomimetic models to study immune responses, indicating that this approach could yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: He, Mei — University of Florida
- Study coordinator: He, Mei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.