Creating 3D models of human pituitary tumors to find new treatments for Cushing Disease
Development of 3-dimensional human pituitary corticotroph tumor cultures as a preclinical model for drug discovery
This study is working on a new way to grow pituitary tumors in the lab to learn more about Cushing Disease, which could help find better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10877036 on NIH RePORTER |
What this research studies
This research focuses on developing a three-dimensional (3D) culture system for human pituitary corticotroph tumors, which are responsible for Cushing Disease. By using advanced techniques like single cell RNA-sequencing and microarray analysis, the researchers aim to understand the genetic and cellular characteristics of these tumors. The goal is to create a reliable model that can be used for drug discovery and to better understand how these tumors behave over time. Patients with Cushing Disease may benefit from the insights gained through this innovative approach, potentially leading to new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Cushing Disease caused by ACTH-secreting pituitary adenomas.
Not a fit: Patients with other types of pituitary tumors or those not affected by Cushing Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for patients suffering from Cushing Disease.
How similar studies have performed: While the approach of creating 3D tumor models is gaining traction, this specific application for Cushing Disease is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Heaney, Anthony P — University of California Los Angeles
- Study coordinator: Heaney, Anthony P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.