Creating 3D models of cancer cells to understand tumor behavior
Project 3: From Networks and Structures to Hierarchical Whole Cell Models of Cancer
This study is looking at how specific genetic changes in tumors can influence how cancer grows and responds to treatment, with the hope of creating better therapies for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10911945 on NIH RePORTER |
What this research studies
This research investigates how unique genetic mutations in tumors affect cancer development and treatment outcomes. By mapping the physical and functional architecture of tumor cells, the project aims to create detailed 3D models of cancer-associated protein complexes. These models will be developed using advanced techniques such as cryo-electron microscopy and mass spectrometry to analyze the molecular components of cancer cells. The goal is to better understand the interactions and pathways that lead to cancer, which could inform more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer or other cancers that exhibit unique genetic mutations.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not have identifiable genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective cancer treatments based on the specific genetic makeup of a patient's tumor.
How similar studies have performed: Other research has shown promise in using 3D modeling and mapping techniques to understand cancer biology, indicating that this approach could be effective.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Ideker, Trey — University of California, San Francisco
- Study coordinator: Ideker, Trey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.