Creating 3D brain circuits on a chip to study brain development and connectivity
Developing 3D brain circuits on-a-chip for in vitro study of human cortico-striatal circuitry development and connectivity
['FUNDING_R21'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10878893
This study is creating a special 3D chip that acts like human brain circuits to help researchers learn more about how certain brain connections develop, which could lead to a better understanding of conditions like schizophrenia.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10878893 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a novel platform that mimics human brain circuits using 3D technology. By creating a microfluidic chip that integrates human stem cell-derived neurons, researchers aim to study the development and connectivity of cortico-striatal circuits, which are crucial for higher-order behaviors and cognition. This approach allows for real-time monitoring of brain circuit dynamics, providing insights into how these circuits function and develop over time. The goal is to better understand the underlying mechanisms of neurodevelopmental disorders like schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurodevelopmental disorders, particularly those with conditions like schizophrenia.
Not a fit: Patients with acute neurological injuries or conditions unrelated to neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for neurodevelopmental disorders.
How similar studies have performed: Previous research has shown promise in using similar microphysiological platforms to study brain function, indicating potential for success in this novel approach.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUO, ZIYUAN — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: GUO, ZIYUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.