Coordination for HIV vaccine work to boost T-cell help for protective antibodies
Administrative Core
This project works to improve T-cell support so HIV vaccines can make stronger neutralizing antibodies for people at risk of infection.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11248836 on NIH RePORTER |
What this research studies
You would be joining a program that uses blood and other samples from people already in cohort studies, together with vaccine experiments in non-human primates, to learn how different T cells help the body make protective antibodies. Scientists are focusing on follicular helper T cells and cytotoxic CD4 and CD8 T cells and on vaccines that include a piece of the virus called the fusion peptide. The Administrative Core at UC Davis coordinates the international team, shares samples and data, and keeps the projects working together smoothly. The core itself does not give treatments but helps the research run efficiently so findings can move toward better vaccines.
Who could benefit from this research
Good fit: Ideal candidates are people enrolled in participating HIV cohort studies or volunteers at partner vaccine trial sites who can provide blood samples or join vaccine studies.
Not a fit: People seeking immediate HIV treatment, those not eligible for vaccine trials, or those hoping for direct clinical therapy now are unlikely to receive direct benefit from this research.
Why it matters
Potential benefit: If successful, this work could help design vaccines that trigger stronger, more protective HIV-neutralizing antibodies and reduce the risk of infection.
How similar studies have performed: Some animal studies and early human trials have shown partial antibody responses, but reliably inducing broadly neutralizing HIV antibodies remains largely unproven.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Hartigan-O'connor, Dennis J. — University of California at Davis
- Study coordinator: Hartigan-O'connor, Dennis J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.