Coordinating team to collect patient samples and fight gut graft‑versus‑host disease after stem cell transplant
Administrative, biospecimen and biostatistical core
This project sets up a team that collects patient samples and uses lab and statistical work to help reduce gut graft‑versus‑host disease in people having stem cell transplants.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11196060 on NIH RePORTER |
What this research studies
From a patient's perspective, this core organizes the investigators and provides administrative, biostatistical, clinical, and bionutrition support so research runs smoothly. It collects blood, stool, and other patient biospecimens plus clinical data from people undergoing hematopoietic cell transplant. Scientists will study mucin‑degrading gut bacteria and use biostatistics and nutrition expertise to link those microbes to transplant-related gut injury. The core aims to enable future clinical interventions to lower intestinal graft‑versus‑host disease risk.
Who could benefit from this research
Good fit: Ideal candidates are people undergoing hematopoietic cell (stem cell) transplant who are willing to provide biospecimens (stool, blood) and clinical information.
Not a fit: People who are not undergoing stem cell transplant, are not at risk for intestinal GVHD, or are unable/unwilling to provide samples are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or lessen intestinal graft‑versus‑host disease after stem cell transplant.
How similar studies have performed: Prior microbiome research and early pilot trials targeting gut bacteria have shown promising signals but remain an active area needing larger clinical studies.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Jenq, Robert — Beckman Research Institute/city of Hope
- Study coordinator: Jenq, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.