Coordinating hub for how aging cells affect immune defense
Admin Core
Researchers are studying how aging cells called senescent cells change immune defenses against infections to improve health for older adults.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11318998 on NIH RePORTER |
What this research studies
This Administrative Core brings together teams working on how senescent cells influence immune responses and control of pathogens. The program uses specialized transgenic mouse models and controlled pathogen exposure experiments alongside advanced single-cell and spatial analysis of tissues to map immune changes. Core A coordinates three research projects and two technical cores so scientists share data, tools, and expertise efficiently. The coordinated approach is meant to speed discovery of ways to protect older adults from infections driven by immune aging.
Who could benefit from this research
Good fit: Ideal candidates for related future clinical work would be older adults with signs of immune aging or people who experience frequent or severe infections.
Not a fit: Young, otherwise healthy people or those with conditions unrelated to immune aging are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, the work could point to therapies that reduce harmful senescent cells or boost immune function, leading to better infection outcomes in older people.
How similar studies have performed: Preclinical studies removing senescent cells have improved health and immune responses in animals, but human trials are still limited and this approach remains relatively new.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Jameson, Stephen C — University of Minnesota
- Study coordinator: Jameson, Stephen C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.