Coordinating center for drug-related liver injury
Drug Induced Liver Injury Network Data Coordinating Center
['FUNDING_U01'] · DUKE UNIVERSITY · NIH-11170678
This project brings hospitals, labs, and experts together to find genetic fingerprints and biomarkers that could help people who develop liver damage from medicines.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11170678 on ClinicalTrials.gov |
What this research studies
You would be connected to a network of clinical sites and a central data team that collect medical information, blood samples, and DNA from people with suspected drug-related liver injury. The Duke-based coordinating center manages the network’s data, keeps quality control, and supports genetic and lab studies to look for markers linked to injury. The network also supports new mechanistic lab studies and possible clinical trials aimed at prevention or treatment. Participation may involve sharing medical records, answering questionnaires, and giving blood or DNA samples.
Who could benefit from this research
Good fit: Ideal candidates are people who have had liver injury suspected to be caused by a medication and who are willing to share medical data and provide blood or DNA samples.
Not a fit: People whose liver problems are clearly unrelated to medications (for example, due to genetic liver disease or certain viral infections) may not benefit directly from this project.
Why it matters
Potential benefit: If successful, the work could lead to tests that predict who is at higher risk and to strategies that prevent or limit liver damage from medicines.
How similar studies have performed: Prior DILIN work and other studies have identified some genetic risk markers for drug-related liver injury, but turning these findings into reliable clinical tests is still an active effort.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARNHART, HUIMAN X — DUKE UNIVERSITY
- Study coordinator: BARNHART, HUIMAN X
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.