Coordinating center for comparing medicines to treat newborn opioid withdrawal
Data Coordinating Center (DCC) for the Neonatal Opioid Withdrawal Syndrome Pharmacological Treatments Comparative Effectiveness Trial (NOWS PhaCET)
This project supports the team running a large trial that compares medicines to help newborns with opioid withdrawal feel better and recover more quickly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project ID | NIH-10912541 on NIH RePORTER |
What this research studies
As a parent, you would see this effort as the central hub that helps hospitals run a shared trial comparing drugs used for newborn opioid withdrawal. The team will set common rules, collect and check data, and use rigorous random assignment so babies get different standard treatments in a fair way. The Data Coordinating Center manages data quality, safety monitoring, and analysis so results from many hospitals can be combined. Results and clear care guidance would be shared publicly to help doctors and families make better treatment choices.
Who could benefit from this research
Good fit: Ideal candidates are newborns (generally within the first few weeks of life) showing signs of opioid withdrawal after being exposed to opioids before birth and who are born at or transferred to participating hospitals.
Not a fit: Babies without prenatal opioid exposure, older children, or people with unrelated medical issues would not directly benefit from this trial.
Why it matters
Potential benefit: If successful, the work could identify the safest and most effective medicine for treating newborn opioid withdrawal and lead to clearer care guidelines and better outcomes.
How similar studies have performed: There have been smaller trials and observational studies of treatments for newborn opioid withdrawal, but large multi-center randomized comparisons like this are limited, so the approach is relatively new and more definitive.
Where this research is happening
Research Triangle Park, United States
- Research Triangle Institute — Research Triangle Park, United States (Active)
Researchers
- Principal investigator: Das, Abhik — Research Triangle Institute
- Study coordinator: Das, Abhik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.