Coordinating center for antibiotic‑resistant gut infections
P01 Administrative Core
This project brings together research to understand and reduce antibiotic‑resistant gut bacteria that can cause dangerous infections in hospitalized and immunocompromised patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11159482 on NIH RePORTER |
What this research studies
If you took part, teams would collect clinical information and stool samples from hospitalized and high‑risk patients to learn how resistant bugs like VRE, CRE/ESBL and C. difficile live in the gut and lead to infections. Labs would compare these pathogens with normal gut bacteria and run experiments to find ways to prevent harmful colonization. The Administrative Core organizes teams, shares data and laboratory resources, and helps move promising findings toward tests or treatments. Overall the program aims to translate lab discoveries into steps that could protect ICU and immunocompromised patients.
Who could benefit from this research
Good fit: Ideal candidates are hospitalized patients—especially those in intensive care or with weakened immune systems—who have received multiple antibiotics or are known to carry gut organisms such as VRE, CRE/ESBL, or C. difficile.
Not a fit: People who have never been hospitalized, have not had recent antibiotic exposure, or whose infections are unrelated to gut colonization are unlikely to directly benefit from this project.
Why it matters
Potential benefit: Could lead to better ways to prevent or treat life‑threatening antibiotic‑resistant gut infections in hospitalized and immunocompromised patients.
How similar studies have performed: Related work on the microbiome and fecal microbiota transplant for C. difficile has shown promise, but preventing and reversing colonization by VRE and CRE remains an active and developing research area.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Arias, Cesar Augusto — Methodist Hospital Research Institute
- Study coordinator: Arias, Cesar Augusto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.