Controlling Spinal Disc Degeneration with Growth Factors
Control of intervertebral disc degeneration via matrix-mediated delivery of platelet-derived growth factors
This project explores a new way to treat spinal disc degeneration by delivering special growth factors to help disc cells stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11062523 on NIH RePORTER |
What this research studies
Spinal disc degeneration is a common cause of back pain, and currently, there isn't a good biological treatment for it. This research aims to develop a new approach using a special gel to deliver natural growth factors, called PDGF, directly to the spinal discs. We want to see if these growth factors can stop or slow down the degeneration process. The team will study how PDGF affects both healthy and diseased human disc cells and also use animal models to understand its full potential.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients at this stage, but future clinical applications would target individuals experiencing intervertebral disc degeneration and related back pain.
Not a fit: Patients whose back pain is not caused by intervertebral disc degeneration would likely not benefit from this specific treatment approach.
Why it matters
Potential benefit: If successful, this approach could lead to the first effective biological treatment for spinal disc degeneration, potentially reducing back pain and improving quality of life for many.
How similar studies have performed: Preliminary laboratory and animal data show promising anti-degenerative effects of PDGF, suggesting this approach builds on existing evidence while exploring novel delivery methods and mechanisms.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Drissi, Moulay Hicham — Emory University
- Study coordinator: Drissi, Moulay Hicham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.