Controlling seizures in Dravet Syndrome by targeting specific channels in the brain
Official title: Dravet Syndrome Anti-Epileptic Control by Targeting GIRK Channels
Funded at Northeastern University · NIH-10995343 · Data updated 2026-11-12
This study is looking at how certain channels in the brain might help control seizures in children with Dravet Syndrome, with the hope of finding new treatments that could make life easier and safer for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $495,972 |
| NIH project number | 5R01NS131467-03 |
| Project ID | NIH-10995343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with Dravet Syndrome, particularly those under the age of 11.
✕Less likely to help
Patients with other forms of epilepsy or those who are older than 11 years may not benefit from this research.
What this research studies
This research focuses on Dravet Syndrome, a severe form of epilepsy that typically begins in infancy and leads to frequent seizures and developmental challenges. The study aims to explore the role of G protein-gated inwardly rectifying K+ (GIRK) channels in controlling seizure activity. By understanding how these channels interact with other proteins in the brain, the research seeks to develop new treatment strategies that could reduce seizure frequency and improve the quality of life for affected children. Patients may benefit from innovative therapies that target these channels, potentially leading to fewer side effects compared to existing medications.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for children with Dravet Syndrome.
How similar studies have gone: Previous research has shown promise in targeting GIRK channels for seizure control, suggesting potential for success in this novel approach.
Where this research is happening
-
Northeastern University
Boston, United States Active
Researchers
- Principal investigator: Logothetis, Diomedes E. — Northeastern University
- Study coordinator: Logothetis, Diomedes E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.