Controlling RNA metabolism in live cells using light and chemicals
Developing optogenetic and chemogenetic approaches to control RNA metabolism in live cells
This study is exploring new ways to control specific messenger RNAs in living cells using light and chemicals, which could help us better understand how our cells make proteins and could lead to new insights for treating diseases related to gene regulation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10925251 on NIH RePORTER |
What this research studies
This research aims to develop innovative methods to manipulate individual messenger RNAs (mRNAs) in live cells, which is crucial for understanding how cells regulate protein synthesis at specific times and locations. By creating optogenetic and chemogenetic tools, researchers will be able to control the behavior of single mRNAs using light or chemical signals. This approach will allow for precise regulation of gene expression in various cellular compartments, enhancing our understanding of fundamental biological processes such as learning, memory, and development. Patients may benefit from insights gained into diseases related to gene regulation and RNA metabolism.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to gene expression dysregulation, such as neurodegenerative diseases or developmental disorders.
Not a fit: Patients with conditions unrelated to RNA metabolism or gene regulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to RNA metabolism and gene regulation.
How similar studies have performed: Other research has shown promise in using optogenetic and chemogenetic approaches for manipulating gene expression, indicating that this methodology has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wu, Bin — Johns Hopkins University
- Study coordinator: Wu, Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.