Controlling protein interactions with synthetic biomaterials to reduce inflammation
Official title: Tunable Surface Coatings to Control Protein Dynamics and Attenuate the FBR
Funded at University of Colorado · NIH-11026429 · Data updated 2026-11-12
This study is looking at how new materials used in implants interact with proteins in your body, to help reduce inflammation and improve recovery after surgery for people getting implants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | February 5, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $697,317 |
| NIH project number | 5R01AI177678-02 |
| Project ID | NIH-11026429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who require surgical implants or biomaterials, such as those undergoing orthopedic or reconstructive surgeries.
✕Less likely to help
Patients who do not require any form of surgical implants or biomaterials may not benefit from this research.
What this research studies
This research investigates how synthetic biomaterials interact with proteins in the body, particularly focusing on the foreign body response (FBR) that occurs after implantation. By using advanced techniques to observe protein behavior on these materials, the researchers aim to understand how certain proteins can trigger inflammation and lead to complications. The goal is to develop surface coatings that can modify these interactions, potentially leading to better biocompatibility and reduced inflammatory responses. Patients may benefit from improved outcomes in surgeries involving implants or biomaterials.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective biomaterials for medical implants, reducing complications and improving patient recovery.
How similar studies have gone: Previous research has shown promise in modifying biomaterial surfaces to improve biocompatibility, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Bryant, Stephanie J — University of Colorado
- Study coordinator: Bryant, Stephanie J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.