Controlling oncogene activation in T-cell leukemia
New control of oncogene activation in T-cell leukemia
['FUNDING_R01'] · WISTAR INSTITUTE · NIH-11061876
This study is looking into how a specific gene called Notch1 affects T-cell acute lymphoblastic leukemia (T-ALL) in both kids and adults, with the hope of finding better and safer treatments for this serious cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WISTAR INSTITUTE (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11061876 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Notch1 signaling in T-cell acute lymphoblastic leukemia (T-ALL), a serious cancer affecting both children and adults. The project aims to understand how Notch1 contributes to the disease and explore new therapeutic strategies that could target this oncogene more effectively. By using advanced models, including Drosophila and mouse models, the researchers are examining the mechanisms that regulate Notch1 activity and its interactions with tumor suppressors. The goal is to identify new ways to combat T-ALL that minimize side effects compared to current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults diagnosed with T-cell acute lymphoblastic leukemia.
Not a fit: Patients with other types of leukemia or those who do not have T-cell acute lymphoblastic leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less toxic treatments for T-cell leukemia.
How similar studies have performed: Previous research has shown promise in targeting oncogenes in leukemia, but this specific approach using Notch1 and UVRAG is relatively novel.
Where this research is happening
PHILADELPHIA, UNITED STATES
- WISTAR INSTITUTE — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIANG, CHENGYU — WISTAR INSTITUTE
- Study coordinator: LIANG, CHENGYU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.