Controlling misfolded proteins to understand neurodegenerative diseases
Chemical Control of Misfolded Protein Fate
This study is exploring how wrongly shaped proteins play a role in diseases like Alzheimer's and Huntington's, and it's for anyone interested in new ways to help treat these conditions by using techniques from cancer treatment to better understand and manage these proteins.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10473133 on NIH RePORTER |
What this research studies
This research focuses on understanding how misfolded proteins contribute to neurodegenerative diseases like Alzheimer's and Huntington's. The team aims to develop new chemical tools that can manipulate the fate of these misfolded proteins in cells and living organisms. By applying techniques from cancer therapy, they hope to gain insights into how these proteins affect cell health and disease progression. This innovative approach could lead to breakthroughs in treating various protein-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, Huntington's disease, or other related neurodegenerative disorders.
Not a fit: Patients with non-neurodegenerative conditions or those without misfolded protein-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of neurodegenerative diseases.
How similar studies have performed: Other research has shown success in using targeted protein degradation techniques in cancer therapy, suggesting potential for similar advancements in neurodegenerative disease treatment.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Ferguson, Fleur Marcia — University of California, San Diego
- Study coordinator: Ferguson, Fleur Marcia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.