Controlling inflammation to prevent post-traumatic osteoarthritis in military personnel
Official title: Achieving Sustained Control of Inflammation to Prevent Post-Traumatic Osteoarthritis (PTOA)
Funded at Philadelphia VA Medical Center · NIH-11056721 · Data updated 2026-11-12
This study is looking at ways to help military service members and veterans avoid developing knee arthritis after an injury by targeting inflammation, and they’re testing a new method to see if it can keep the joints healthier and working better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01RX003988-03 |
| Project ID | NIH-11056721 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are active duty military personnel and veterans who have experienced knee injuries.
✕Less likely to help
Patients who have not suffered knee injuries or those with pre-existing osteoarthritis unrelated to trauma may not benefit from this research.
What this research studies
This research focuses on preventing post-traumatic osteoarthritis (PTOA) in military service members and veterans by targeting inflammation in the knee joint after injury. The team aims to develop a novel method to modulate the inflammatory response using a specific blockade of a receptor involved in inflammation. By employing a large-animal model, they will test the effectiveness of this approach in reducing the progression of PTOA and improving joint function. The study builds on previous findings that link inflammation to the severity of osteoarthritis.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of developing osteoarthritis after knee injuries in military personnel.
How similar studies have gone: Previous research has shown promise in targeting inflammation to improve outcomes in osteoarthritis, making this approach a potentially valuable advancement.
Where this research is happening
-
Philadelphia VA Medical Center
Philadelphia, United States Active
Researchers
- Principal investigator: Scanzello, Carla Rose — Philadelphia VA Medical Center
- Study coordinator: Scanzello, Carla Rose
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.