Controlling immune responses to improve outcomes after stem cell transplants
Official title: The regulation of innate immune sensors to control GVHD and GVL after allogeneic hematopoietic stem cell transplantation
Funded at Stanford University · NIH-10864817 · Data updated 2026-11-12
This study is looking at ways to help patients with acute myeloid leukemia have safer and more effective stem cell transplants by finding out how to better manage the immune system and reduce complications like graft-versus-host disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 16, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $103,942 |
| NIH project number | 5K00CA245728-06 |
| Project ID | NIH-10864817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia (AML) who are considering or preparing for allogeneic hematopoietic stem cell transplantation.
✕Less likely to help
Patients who are not undergoing stem cell transplantation or those with conditions other than AML may not benefit from this research.
What this research studies
This research investigates how to regulate the innate immune system to reduce complications like graft-versus-host disease (GVHD) while enhancing the beneficial effects of stem cell transplants for patients with acute myeloid leukemia (AML). The study focuses on understanding the role of specific immune sensors that can trigger inflammation and immune responses during and after transplantation. By identifying these mechanisms, the research aims to develop strategies that could improve patient outcomes and reduce the risks associated with stem cell transplants.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for patients undergoing stem cell transplants, potentially reducing the incidence of GVHD and improving survival rates.
How similar studies have gone: Previous research has shown promising results in regulating immune responses in similar contexts, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Bader, Cameron Scott — Stanford University
- Study coordinator: Bader, Cameron Scott
Related research
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Researchers are creating patient-specific lab models of the gut, liver, and blood to better understand and prevent GVHD after bone marrow transplant, with a focus on children.
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Optimizing stem cell transplants to treat non-malignant blood diseases
A researcher is pursuing a five-year plan to improve stem cell transplantation strategies for non-cancer blood illnesses, with a focus on safer conditioning, better stem cell collection, and gene editing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.