Controlling immune responses to improve outcomes after stem cell transplants
The regulation of innate immune sensors to control GVHD and GVL after allogeneic hematopoietic stem cell transplantation
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-10864817
This study is looking at ways to help patients with acute myeloid leukemia have safer and more effective stem cell transplants by finding out how to better manage the immune system and reduce complications like graft-versus-host disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10864817 on ClinicalTrials.gov |
What this research studies
This research investigates how to regulate the innate immune system to reduce complications like graft-versus-host disease (GVHD) while enhancing the beneficial effects of stem cell transplants for patients with acute myeloid leukemia (AML). The study focuses on understanding the role of specific immune sensors that can trigger inflammation and immune responses during and after transplantation. By identifying these mechanisms, the research aims to develop strategies that could improve patient outcomes and reduce the risks associated with stem cell transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia (AML) who are considering or preparing for allogeneic hematopoietic stem cell transplantation.
Not a fit: Patients who are not undergoing stem cell transplantation or those with conditions other than AML may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for patients undergoing stem cell transplants, potentially reducing the incidence of GVHD and improving survival rates.
How similar studies have performed: Previous research has shown promising results in regulating immune responses in similar contexts, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BADER, CAMERON SCOTT — STANFORD UNIVERSITY
- Study coordinator: BADER, CAMERON SCOTT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.