Controlling immune cell development and function using natural products
Transcript-selective translational control of Th17 cell development and function
This study is looking at how a plant-based compound can help control certain immune cells that are involved in inflammation, which could lead to new treatments for people dealing with inflammatory conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth-Hitchcock Clinic NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project ID | NIH-10753258 on NIH RePORTER |
What this research studies
This research investigates how certain natural products can influence the development and function of specific immune cells known as Th17 cells. By using a compound derived from plants, the study aims to understand how it can block the differentiation of these cells, which play a crucial role in immune responses. The approach involves examining the molecular mechanisms by which this compound affects protein synthesis in immune cells, potentially leading to new treatments for inflammatory conditions. Patients may benefit from insights gained about immune regulation and potential new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions characterized by excessive Th17 cell activity, such as autoimmune diseases.
Not a fit: Patients with conditions unrelated to Th17 cell function or those not experiencing inflammatory responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for inflammatory diseases by better controlling immune responses.
How similar studies have performed: Previous research has shown promise in using natural products to modulate immune responses, suggesting that this approach may yield beneficial results.
Where this research is happening
Lebanon, United States
- Dartmouth-Hitchcock Clinic — Lebanon, United States (Active)
Researchers
- Principal investigator: Sundrud, Mark Scott — Dartmouth-Hitchcock Clinic
- Study coordinator: Sundrud, Mark Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.