Controlling Gut Inflammation
Cytokine regulation of mucosal inflammation
This research looks for new ways to prevent and reverse inflammation in the digestive system, which affects conditions like allergies, inflammatory bowel disease, and graft-versus-host disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11163870 on NIH RePORTER |
What this research studies
We are exploring how certain immune cells, called ILC3s, help manage inflammation in the gut by sensing and regulating important signals. Our previous work showed that these cells use a molecule called CTLA-4 to keep gut inflammation in check. We also found that these interactions are not working correctly in people with inflammatory bowel disease (IBD). This new phase of research aims to understand exactly how these cells and molecules work together, hoping to find new targets for treatments.
Who could benefit from this research
Good fit: This foundational research is for patients interested in the underlying causes of chronic gut inflammation, including those with inflammatory bowel disease, severe allergies, or graft-versus-host disease.
Not a fit: Patients seeking immediate new treatments or direct clinical trial participation may not find direct benefit from this basic science research at this stage.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent or reduce severe inflammation in the gut for conditions like IBD, allergies, and GVHD.
How similar studies have performed: Previous work from this team has already shown significant, paradigm-shifting results regarding how immune cells regulate gut inflammation, and new preliminary data supports this continued direction.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Sonnenberg, Gregory F — Weill Medical Coll of Cornell Univ
- Study coordinator: Sonnenberg, Gregory F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.