Controlling Genes with Chemical Signals
Elucidating Mechanisms and Design Principles for Chemically Inducible Expression Modulation
This research aims to develop new ways to precisely control how genes work in our bodies using chemical signals, which could help us understand and treat various health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-11139589 on NIH RePORTER |
What this research studies
This project is developing new molecular tools that can precisely turn genes on or off in specific cells or at certain times. We are learning how to design these tools to respond to chemical signals, which could help us better understand how our bodies work and how diseases develop. The work involves using advanced techniques like Cas9 gene editing and machine learning to create systems that can rapidly and strongly control gene activity. Our goal is to create fundamental insights into how natural signals control genes, which can then be applied to correct problems caused by genes not working correctly.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients at this time, but future applications may benefit individuals with conditions linked to gene expression problems.
Not a fit: Patients seeking immediate clinical treatments or those whose conditions are not related to gene expression modulation may not directly benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could lead to new, highly targeted therapies for diseases caused by genes that are not working properly, allowing for more controlled and safer treatments.
How similar studies have performed: This research aims to generate novel fundamental insights, building upon existing knowledge in gene expression control but tackling significant engineering challenges in new ways.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Khakhar, Arjun — Colorado State University
- Study coordinator: Khakhar, Arjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.