Controlling gene expression to improve therapies for diseases
Site-specific control of human gene regulation for therapeutically applicable mechanistic insights
This study is looking at ways to better control how our genes work, which is important for understanding and treating different diseases, and it uses cutting-edge technology to help create personalized treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10878858 on NIH RePORTER |
What this research studies
This research investigates how to precisely control human gene expression, which is crucial for understanding and treating various diseases. It focuses on the mechanisms that regulate gene expression, including chromatin structure and modifications, and employs advanced CRISPR technology to edit the epigenome. By exploring how different factors influence gene activity in various cell types, the research aims to develop new therapeutic strategies that can be tailored to individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders or diseases linked to dysregulated gene expression.
Not a fit: Patients with conditions unrelated to gene regulation or those who do not have a genetic component to their illness may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that more effectively target and treat a wide range of diseases by precisely regulating gene expression.
How similar studies have performed: Other research has shown promising results using CRISPR technology for gene regulation, indicating potential for success in this area.
Where this research is happening
Houston, United States
- Rice University — Houston, United States (Active)
Researchers
- Principal investigator: Hilton, Isaac — Rice University
- Study coordinator: Hilton, Isaac
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.