Controlling cell behavior by adjusting pH levels in their environment
Official title: Cell Control via Spatiotemporal Microenvironmental pH Modulation
Funded at University of Massachusetts Amherst · NIH-10931415 · Data updated 2026-11-12
This study is exploring how to carefully adjust the acidity around cells to help them work better, which could lead to new ways to improve treatments in areas like healing tissues and delivering medications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $379,990 |
| NIH project number | 5R35GM151128-02 |
| Project ID | NIH-10931415 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that could benefit from advanced cell therapies, such as cancer or cardiovascular diseases.
✕Less likely to help
Patients with stable conditions that do not require innovative cell-based treatments may not benefit from this research.
What this research studies
This research focuses on how the pH levels in the microenvironment of cells can be precisely controlled to influence their behavior and function. By developing new methods to modulate pH in real-time and with high spatial resolution, the project aims to improve applications in cell biology, tissue engineering, and regenerative medicine. The approach utilizes advanced nanoelectrochemical techniques with graphene-based microelectrodes to achieve this control, which could lead to significant advancements in drug delivery and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for various diseases by enabling precise control over cell behavior.
How similar studies have gone: While the approach of using pH modulation for cell control is innovative, similar techniques in cell manipulation have shown promise in preliminary studies.
Where this research is happening
-
University of Massachusetts Amherst
Hadley, United States Active
Researchers
- Principal investigator: Ping, Jinglei — University of Massachusetts Amherst
- Study coordinator: Ping, Jinglei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.