Controlling calcium levels to prevent heart rhythm problems
Partial and Controlled Depletion of SR Calcium by RyR Agonists Prevents Calcium-dependent Arrhythmias
This study is looking at how adjusting calcium levels in heart cells might help stop dangerous heart rhythms, and it could lead to new treatments that make your heart healthier and safer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11001921 on NIH RePORTER |
What this research studies
This research investigates how manipulating calcium levels in heart cells can help prevent dangerous heart rhythms, known as arrhythmias. By using specific compounds that target ryanodine receptors, the study aims to reduce calcium overload, which is a key factor in triggering these arrhythmias. The approach involves testing these compounds in both laboratory settings and potentially in clinical scenarios to assess their effectiveness in stabilizing heart function. Patients may benefit from new treatment options that could improve heart health and reduce the risk of arrhythmias.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals, particularly children and young adults, who are at risk for arrhythmias due to conditions like Catecholaminergic Polymorphic Ventricular Tachycardia or other heart-related issues.
Not a fit: Patients with arrhythmias caused by non-calcium overload mechanisms or those who do not have a history of arrhythmias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of life-threatening heart arrhythmias in patients.
How similar studies have performed: Previous research has shown promise in using similar approaches to manage calcium levels in heart cells, indicating potential for success in this area.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Valdivia, Hector H — University of Wisconsin-Madison
- Study coordinator: Valdivia, Hector H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.