Controlling brain connections with light
Trans-synaptic optical control of user-defined synaptic connections
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-10732081
This study is exploring a new way to use light to control brain connections that are important for learning and memory, which could help us better understand how our brains work and lead to new treatments for brain-related conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10732081 on ClinicalTrials.gov |
What this research studies
This research investigates a novel method to optically control specific synaptic connections in the brain, which are crucial for functions like learning and memory. By developing a system that allows for reversible inhibition of these connections, the researchers aim to enhance our understanding of how different neurons communicate and influence behavior. The approach involves engineering light-sensitive proteins that can be activated to manipulate synaptic activity, which will be tested in both laboratory settings and living mice. This could lead to breakthroughs in how we study and potentially treat neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with neurological conditions that affect learning and memory.
Not a fit: Patients with conditions unrelated to synaptic function or those who do not reside near the research location may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into brain function and lead to innovative treatments for neurological disorders.
How similar studies have performed: While the approach of optically controlling synaptic connections is innovative, similar methodologies have shown promise in other areas of neuroscience research.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COPITS, BRYAN — WASHINGTON UNIVERSITY
- Study coordinator: COPITS, BRYAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease